Optimization: Influence of Granules size and Disintegrants

The optimization of formulation is the next task to formulate an effective rapid dispersible tablet with ideal wetting, dispersion properties to achieve rapid release profile of finished product. In preliminary work, the initial formulation was established to enhance the solubility and rapid release of Tolfenamic acid, but the optimization of size of granules and quantity of disintegrants was not the aim of experiment. This resulting a non uniform wetting and dispersion of tablets as per the standard of dispersible tablets and Orodispersible tablets specified in British pharmacopoeia. There were some residues of large granules through 710 μm mesh observed during evaluation of dispersion test. Delay in dispersion times due to large granules may be within accepted limits, but high variability in dispersion directly impacts the quality parameters of finished product.